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从分娩当日建立幼鼠缺锌动物模型，并设对照组，于５６日龄进行实验。原子吸收分光光度计检测锌含量，放免法测定内皮素含量，罗向东法测定一氧化氮（ＮＯ）。结果：（１）缺锌组幼鼠体重、脑重、血清和脑组织锌均明显低于对照组，（２）缺锌幼鼠血浆、皮层和小脑内皮素含量均明显低于对照组，而血浆和海马ＮＯ含量均明显高于对照组。可见缺锌使幼鼠血浆和脑组织内皮素含量明显减少，ＮＯ含量显著增加，这也可能是缺锌使脑发育和功能障碍的机制之一。
From the day of birth, a model of zinc deficiency in young rats was established, and a control group was set up to conduct experiments at 56 days of age. Atomic absorption spectrophotometer detection of zinc content, radioimmunoassay determination of endothelin content, Luo Xiangdong method for the determination of nitric oxide (NO). Results: (1) The body weight, brain weight, zinc in serum and brain tissue were significantly lower in zinc deficiency group than in control group. (2) The content of plasma, cortex and cerebellum in zinc deficient rats were significantly lower than that in control group NO content in plasma and hippocampus were significantly higher than that in control group. It can be seen that zinc deficiency significantly decreased the content of endothelin in plasma and brain tissues of rats, and the content of NO significantly increased. This may also be one of the mechanisms of zinc deficiency in brain development and dysfunction.