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激素事后片是一种有效的补救性避孕措施,合并使用雌、孕激素作为事后片可以比分别用药时各激素的用量减少,因而减少了副作用,但仍保持其有效性。这种合并用药的作用机制包括抑制排卵、改变黄体功能和干扰为植入所必要的宫内膜环境。本文中作者报告了以消旋18甲与炔雌醇合并或单用丹那唑作为事后避孕药妇女宫内膜的雌、孕激素受体含量及异柠檬酸脱氢酶(ICDH)活性的变化。 17名对象志愿参与本研究,年龄为20～40岁,体健,月经周期规则(23～35天),除2例外,其余均已用Hulka夹绝育,2例中1例用子宫帽、1例用安全期避孕均已超过6个月。其中8例用消旋18甲1mg+炔雌醇0.1mg(Eugynon50)9例单用丹那唑400mg。所有研究对象于参与研究前作体
Hormone postexposure is an effective remedial contraceptive method. The combination of estrogen and progesterone as an aftereffective tablet can reduce the dosage of each hormone when compared with each other, thus reducing the side effects but still maintaining its effectiveness. The mechanisms of action of this combination include suppressing ovulation, altering the function of the corpus luteum, and interfering with the endometrial environment necessary for implantation. In this paper, the authors report changes in estrogen and progesterone receptor content and isocitrate dehydrogenase (ICDH) activity in endometrium of women with metronidazole combined with metronidogenol or danazol alone. Seventeen volunteers participated in the study voluntarily. The age ranged from 20 to 40 years old. Body health and menstrual cycle rule (23-35 days), except for 2 cases, had been sterilized with Hulka clip. In 2 cases, 1 case had a uterine cap and 1 Cases of contraception during the safe period have been more than 6 months. Among them, 8 cases were treated with racemic 18 mg 1 mg + ethinyl estradiol 0.1 mg (Eugynon 50) and 9 cases were treated with monoazamazole 400 mg. All subjects participated in pre-research work