特发性广泛性食管痉挛(简称IDOS)是以吞咽困难、胸痛或两者兼有为特征的疾病。食管测压显示食管下2/3处有长时期强烈的、反复和同步的收缩,其病因不明。Eckhard等和Hollis等分别指出五肽胃泌素可使IDOS患者发生食管痉挛和使正常人食管下端括约肌压力增加。推测对内源性胃泌素的超敏性可能是本病症状发生之基础,而给予五肽胃泌素则可作为激发 Idiopathic generalized esophageal spasm (IDOS) is a condition characterized by dysphagia, chest pain, or both. Esophageal manometry showed 2/3 of the esophagus has a long period of intense, repeated and synchronized contraction, the etiology is unknown. Eckhard et al. And Hollis et al., Respectively, indicate that pentagastrin can cause esophageal spasm in IDOS patients and increase the pressure of the lower esophageal sphincter in normal humans. It is speculated that the hypersensitivity to endogenous gastrin may be the basis for the onset of symptoms of this disease, whereas pentagastrin may be provoked