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目的分析卵巢浆液性腺癌中WWOX和PTEN的表达及临床病理意义。方法采用免疫组化Eli Vision两步法监测卵巢浆液性囊腺瘤,交界性浆液性囊腺瘤和浆液性腺癌中WWOX和PTEN蛋白的表达。结果卵巢浆液性腺癌中WWOX蛋白和PTEN蛋白阳性率分别为53.3%和44.4%,高、低级别卵巢浆液性腺癌中WWOX蛋白阳性率分别为48.4%和64.2%,PTEN蛋白阳性率分别为35.5%和64.2%,显著低于其他各组(P<0.05)。高级别浆液性腺癌中WWOX和PTEN蛋白阳性率显著低于低级别,差异具有统计学意义(P<0.05)。结论卵巢浆液性腺癌中WWOX和PTEN蛋白表达显著降低,二者在高、低级别浆液性腺癌中的表达有差异。
Objective To analyze the expression of WWOX and PTEN in ovarian serous adenocarcinoma and its clinicopathological significance. Methods The expression of WWOX and PTEN protein in ovarian serous cystadenoma, borderline serous cystadenoma and serous adenocarcinoma were detected by immunohistochemical Eli Vision two-step method. Results The positive rates of WWOX protein and PTEN protein in ovarian serous adenocarcinoma were 53.3% and 44.4% respectively. The positive rates of WWOX protein in high and low grade ovarian serous adenocarcinoma were 48.4% and 64.2%, respectively. The positive rates of PTEN protein were 35.5% And 64.2%, significantly lower than other groups (P <0.05). The positive rates of WWOX and PTEN protein in high grade serous adenocarcinoma were significantly lower than those in lower grade, the difference was statistically significant (P <0.05). Conclusions The expression of WWOX and PTEN protein in ovarian serous adenocarcinoma was significantly lower than that in normal ovarian serous adenocarcinoma.