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目的评价大剂量醛氢叶酸(CF)加氟脲嘧啶(5-FU)持续48h滴注联合放疗方案治疗晚期直肠癌的疗效及毒副反应,探讨晚期直肠癌较合理的治疗方案。方法对30例晚期直肠癌患者采用大剂量CF(200mg/m2)+5-FU(3.2g/m2)持续48h滴注联合放疗,化疗平均2.67个疗程。结果完全缓解(CR)4例,部分缓解(PR)14例,稳定(NC)11例,进展(PD)1例,总有效率为60%,主要的毒副反应为恶心、呕吐、口腔黏膜炎、骨髓抑制及脱发。结论大剂量CF+5-FU持续48h滴注联合放疗治疗晚期直肠癌疗效好、毒副反应轻。
Objective To evaluate the efficacy and side effects of high-dose infusion of leucovorin (CF) and fluorouracil (5-FU) for 48 h in combination with radiotherapy for advanced rectal cancer, and to explore a more reasonable treatment plan for advanced rectal cancer. Methods 30 patients with advanced rectal cancer were treated with high-dose CF (200mg/m2) +5-FU (3.2g/m2) for 48h infusion and radiotherapy. The average course of chemotherapy was 2.67 cycles. Results Complete remission (CR) 4 cases, partial remission (PR) 14 cases, stable (NC) 11 cases, progress (PD) 1 case, total effective rate was 60%, the main toxicities were nausea, vomiting, oral mucosa Inflammation, bone marrow suppression and hair loss. Conclusion High-dose CF+5-FU continuous infusion for 48 h combined with radiotherapy has good curative effect and mild side effects in the treatment of advanced rectal cancer.