虽然Rossolino在1901年首先描述了一个特殊的联合征即面部水肿、面神经瘫痪和沟纹舌,然而该综合征是以Melkersson和Rosenthal来命名的。综合征前两个体征在1931年由Melkersson描述过,而第三个体征在1931年由Rosenthal所报告。Rosenthal同时指出了该综合征偶而有家族关系。到现在,其病因尚不清楚,没有可靠的证据能说明感染与综合征有关,然而偶尔伴随有先天性巨结肠,耳硬化或颅咽管瘤。 Although Rossolino first described in 1901 a special conjunctiva that is facial edema, facial paralysis, and grooved tongue, the syndrome is named after Melkersson and Rosenthal. The first two signs of the syndrome were described by Melkersson in 1931, and the third was reported by Rosenthal in 1931. Rosenthal also pointed out that the syndrome occasionally has a family relationship. Until now, the etiology of the disease is not known. There is no reliable evidence that the infection is associated with the syndrome, but occasionally with congenital megacolon, otosclerosis or craniopharyngioma.