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目的:急性放射性肺损伤是胸部肿瘤放疗引起的常见并发症,该研究着眼于“益气养阴”法,探索中医药干预放射性肺损伤方案,以期提高患者预后和生活质量。方法:纳入32例随机分成两组,对照组行西医常规治疗,中药实验组以益气养阴联合西药干预,4周后通过KPS及CRP评分、TGF2-β1含量、血气变化等进行评价。结果:较对照组,实验组症状积分明显减轻,且TGF2-β1含量较单对照组降低(P<0.05);其中,两组均有进展至3期的患者,对照组6例,实验组2例,HCO3-与PaO2无明显差异。结论:西医常规治疗放射性肺损伤疗效有限,采用益气养阴中药联合西医治疗策略可能具有更加明显的优势。
OBJECTIVE: Acute radiation-induced lung injury is a common complication caused by radiotherapy of thoracic tumors. This study focuses on the method of “supplementing qi and nourishing the yin” to explore the intervention of Chinese medicine in radiation-induced lung injury in order to improve the prognosis and quality of life of patients. Methods: Thirty-two cases were randomly divided into two groups. The control group received routine western medicine treatment. The Chinese herbal medicine group was given Yiqi Yangyin combined with western medicine intervention. After 4 weeks, the KPS and CRP score, TGF-β1 content and blood gas changes were evaluated. Results: Compared with the control group, the symptom score of the experimental group was significantly reduced, and the content of TGF-β1 was lower than that of the control group (P <0.05). Among the two groups, there were 6 patients in the control group, 6 in the control group, For example, HCO3- and PaO2 no significant difference. Conclusion: The routine treatment of radiation-induced lung injury in western medicine has limited efficacy. It may be more obvious to adopt the TCM method of supplementing qi and nourishing yin in combination with western medicine.