近年来,由于重症监护病房(ICU)内危重患者频繁使用侵入性操作、广谱抗生素、激素及免疫抑制剂,导致细菌感染逐年增多。尤其是革兰阳性球菌感染比例日趋严重,包括金黄色葡萄球菌、凝固酶阴性葡萄球菌、肠球菌等,同时危重患者发生阳性菌感染往往病情较重,病死率高,尤其是耐甲氧西 In recent years, due to frequent use of invasive procedures, broad-spectrum antibiotics, hormones and immunosuppressive agents in critically ill patients in intensive care units (ICU), bacterial infections have been increasing year by year. In particular, Gram-positive cocci infections become more and more serious, including Staphylococcus aureus, coagulase-negative staphylococcus, enterococci, etc. At the same time, positive bacteria infections in critically ill patients are often in severe condition with high mortality, especially methicillin-resistant