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目的探讨不同临床分期宫颈癌患者血清Th1和Th2细胞因子水平与Th1、Th2细胞因子表达相关关系。方法选择72例宫颈癌患者作为病例组,并进行FIGO临床分期,同时选择30例健康体检女性作为对照组,Elisa法检测干扰素-γ(IFN-γ)、白介素-2(IL-2)等Th1细胞因子水平和白介素-4(IL-4)、白介素-6(IL-6)等Th2细胞因子水平,并计算Th1/Th2比值。结果病例组患者血清IFN-γ、IL-2、IL-4和IL-6水平高于对照组,而IFN-γ/IL-4、IFN-γ/IL-6、IL-2/IL-4和IL-2/IL-6比值低于对照组,差异有统计学意义(P<0.05);随着宫颈癌临床分期的加重,血清Th1和Th2细胞因子水平逐渐增高,而Th1/Th2细胞因子比值则逐渐降低,差异均有统计学意义(P<0.05);病例组患者血清IFN-γ与IL-4、IL-6分别呈明显正相关(r=0.533,0.502),血清IL-2与IL-4、IL-6也分别呈明显正相关(r=0.606,0.574),差异均有统计学意义(P<0.05)。结论宫颈癌患者Th2细胞因子水平异常增高,Th1/Th2细胞因子动态平衡发生紊乱,并且二者互相影响。
Objective To investigate the relationship between serum levels of Th1 and Th2 cytokines and Th1 and Th2 cytokines in patients with different clinical stages of cervical cancer. Methods Seventy-two cases of cervical cancer were selected as case group and FIGO clinical stage was performed. Thirty healthy women were selected as control group. The levels of IFN-γ, IL-2, Th1 cytokines and Th2 cytokines such as interleukin-4 (IL-4) and interleukin-6 (IL-6), and calculate Th1 / Th2 ratio. Results Serum levels of IFN-γ, IL-2, IL-4 and IL-6 were significantly higher in case group than those in control group, while the levels of IFN-γ / IL-4, IFN- γ / IL-6 and IL- 2 / IL-4 (P <0.05). With the increase of clinical stage of cervical cancer, serum levels of Th1 and Th2 cytokines gradually increased, while Th1 / Th2 cytokines (P <0.05). Serum levels of IFN-γ were positively correlated with IL-4 and IL-6 (r = 0.533, 0.502, IL-4 and IL-6 also showed a significant positive correlation (r = 0.606,0.574), the differences were statistically significant (P <0.05). Conclusion The levels of Th2 cytokines in patients with cervical cancer are abnormally elevated, the dynamic balance of Th1 / Th2 cytokines is disrupted, and the two affect each other.