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目的研究亚硒酸钠对实验性矽肺的作用,探讨矽肺的发病机制及寻找防治矽肺较理想的药物。方法观察亚硒酸钠对各组大鼠实验性矽肺治疗后的病理形态改变。结果亚硒酸钠组的脂质过氧化物(LPO)含量明显低于石英组,喂养一个月的亚硒酸钠治疗组的体重增加(70±14)g明显高于矽肺组(59±10)g,肺重(2.3±0.4)g明显低于矽肺组(3.6±1.1)g,矽结节数量(66.67±3.44)个明显少于矽肺组(84.17±7.99)个,矽结节纤维化程度(1.33±0.52)明显轻于矽肺组(2.17±0.41);同样处理两个月的亚硒酸钠治疗组的体重增加(64±17)g明显高于矽肺组(28±18)g,肺重(2.5±0.6)g明显低于矽肺组(5.2±1.3)g,矽结节数量(73.20±2.39)个明显少于矽肺组(121.00±2.65)个,矽结节纤维化程度(1.60±0.55)明显轻于矽肺组(3.20±0.45)。结论亚硒酸钠能拮抗生物膜的脂质过氧化作用,能减轻矽肺病变,有望成为防治矽肺的理想药物。
Objective To study the effect of sodium selenite on experimental silicosis and to explore the pathogenesis of silicosis and find out the ideal drug for preventing and treating silicosis. Methods The pathological changes of sodium selenite in rats after experimental silicosis were observed. Results The content of lipid peroxide (LPO) in sodium selenite group was significantly lower than that in quartz group. The weight gain (70 ± 14) g in sodium selenite group was significantly higher than that in silicosis group (59 ± 10) ), lung weight (2.3 ± 0.4) g was significantly lower than that of silicosis group (3.6 ± 1.1) g, the number of silicone nodules (66.67 ± 3.44) was significantly less than that of silicosis group (84.17 ± 7.99) (1.33 ± 0.52) was significantly lower than that of silicosis group (2.17 ± 0.41). Body weight gain (64 ± 17) g in sodium selenite group treated for two months was significantly higher than that in silicosis group (28 ± 18) g, The lung weight (2.5 ± 0.6) g was significantly lower than that of the silicosis group (5.2 ± 1.3) g, and the number of silicone nodules (73.20 ± 2.39) was significantly less than that of silicosis group (121.00 ± 2.65) ± 0.55) was significantly lighter than the silicosis group (3.20 ± 0.45). Conclusion Sodium selenite can antagonize the lipid peroxidation of biofilm and reduce the pathological changes of silicosis. It is expected to become an ideal drug for the prevention and treatment of silicosis.