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广泛用于生物单分子研究的光镊力谱技术,其皮牛级的力学测量性能依赖于光阱刚度和微球位移的精确测量.为实现纳米精度的位移测量能力,在分析背焦平面干涉法测量精度的基础上,提出了基于四象限光电探测器(QPD)和现场可编程门阵列(FPGA)开发板的测量方案,并建立了相应的测量系统.实验采用精密位移台驱动固定微球往复经过光阱,对系统的测量性能进行了标定.结果表明,该方案的探测灵敏度达到12.1 m V/nm,探测精度优于3 nm,探测分辨力小于1 nm,满足生物单分子拉伸力谱测试对微球位移探测的要求.
The optical tweezers force spectrum technique, which is widely used in biological monomolecular research, has its mechanical properties depend on the optical trap stiffness and the precise measurement of microsphere displacement.In order to achieve the nanometer precision displacement measurement capability, (QPD) and field programmable gate array (FPGA) development board are proposed based on the measurement accuracy of the method and the corresponding measuring system.An experiment using a precision displacement stage to drive the fixed microspheres The results show that the detection sensitivity of this scheme reaches 12.1 mV / nm, the detection accuracy is better than 3 nm and the detection resolution is less than 1 nm, which meets the biomolecule tensile force Spectral testing of microsphere displacement detection requirements.