【摘 要】
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研究表明SDF-1(CXCL12)能调控许多重要的生物过程,包括心脏与神经的发育、干细胞运动、血管形成、凋亡及肿瘤发生。历来认为,SDF-1是通过CXCR4这个唯一的受体来调控这些不同
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研究表明SDF-1(CXCL12)能调控许多重要的生物过程,包括心脏与神经的发育、干细胞运动、血管形成、凋亡及肿瘤发生。历来认为,SDF-1是通过CXCR4这个唯一的受体来调控这些不同的过程。本研究发现了SDF-1的一个新受体,称为CX-CR7。CXCR7除了能与SDF-1高亲和力结合外,还能结合另外
Studies have shown that SDF-1 (CXCL12) regulates many important biological processes, including heart and nerve development, stem cell motility, angiogenesis, apoptosis and tumorigenesis. Historically, SDF-1 regulates these diverse processes through the sole receptor for CXCR4. This study found a new receptor for SDF-1, called CX-CR7. CXCR7 binds to SDF-1 in addition to its high affinity
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