组织型纤溶酶原激活物 (t- PA)是一种来源于血管内皮、启动内源性纤溶作用的关键酶 ;作为对血栓性动脉闭塞的反应 ,活性 t- PA急性的释放调解可在数分钟内出现。目的　该项研究旨在观察外科手术对猪冠脉血管床中t- PA释放动力学的影响。方法　选取麻醉猪 (n=16 ) ,分别于胸骨切 Tissue plasminogen activator (t-PA) is a key enzyme that originates from the vascular endothelium and initiates endogenous fibrinolysis. As a response to thrombotic arterial occlusion, the acute release of active t-PA may mediate Appear in a few minutes. Purpose This study aimed to observe the effect of surgery on t-PA release kinetics in a porcine coronary vessel bed. Methods Anesthetic pigs (n = 16) were selected and sutured respectively