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[目的]探讨血清胆汁酸(TBA)水平和粪便pH值在肝硬化中的临床价值。[方法]对70例肝硬化患者(肝硬化组)、40例慢性胃炎患者(对照组)采用全自动生化分析仪检测其TBA、精密pH试纸检测其粪便pH值。[结果]肝硬化组患者外周血TBA水平、粪便pH值分别为(52.88±47.88)μmol/L、6.88±0.71,对照组分别为(8.695±4.70)μmol/L、5.860±0.27;2组比较,血清TBA水平及粪便pH值均差异有统计学意义(P<0.01)。肝硬化组患者随着Child-pugh分级升高而TBA水平升高,各级间比较差异有统计学意义(P<0.05);但不同Childpugh分级患者粪便pH值无改变。外周血TBA水平、粪便pH值与肝硬化病因无明显相关性。[结论]TBA、粪便pH值是反映肝硬化患者肝细胞损害的敏感指标之一,由于影响粪便pH值的因素较多,其预测及判断肝硬化预后及病情的严重程度的敏感性、特异性不如TBA。
[Objective] To investigate the clinical value of serum bile acid (TBA) and stool pH value in cirrhosis. [Method] The TBA of 70 cirrhotic patients (cirrhosis group) and 40 chronic gastritis patients (control group) were detected by automatic biochemical analyzer. The pH of the feces was detected by precision pH test paper. [Results] The levels of TBA and faecal pH in peripheral blood of patients with liver cirrhosis were (52.88 ± 47.88) μmol / L and 6.88 ± 0.71, respectively, and those of the control group were (8.695 ± 4.70) μmol / L and 5.860 ± 0.27 respectively; , Serum TBA level and stool pH values were significantly different (P <0.01). The level of TBA in patients with cirrhosis increased with the increase of Child-pugh grade, and there was significant difference among all levels (P <0.05). However, there was no change of pH in feces of Childpugh patients. TBA levels in peripheral blood, faecal pH and etiology of cirrhosis no significant correlation. [Conclusion] TBA and pH value of feces are one of the sensitive indexes to reflect the damage of liver cells in cirrhotic patients. Because of the many factors affecting the pH value of feces, the sensitivity and specificity of predicting and predicting the prognosis of liver cirrhosis and the severity of the disease Not as good as TBA.