葡萄糖转运蛋白I(GLUT1)是哺乳动物细胞葡萄糖跨膜转运的主要载体。与正常细胞相比,恶性肿瘤细胞一个显著特点就是糖代谢率的升高,相应的负责细胞葡萄糖摄取的GLUT1在恶性肿瘤组织中高表达。GLUT1的高表达可作为细胞的恶性转化的标志,并与肿瘤细胞的增殖、侵袭能力密切相关,有望成为恶性肿瘤早期诊断、判断预后的一种新标记物。 Glucose transporter 1 (GLUT1) is the major carrier of glucose transmembrane transport in mammalian cells. A striking feature of malignant tumor cells compared to normal cells is an increase in the rate of glucose metabolism, with the corresponding GLUT1 responsible for cellular glucose uptake highly expressed in malignant tumors. High expression of GLUT1 can be used as a marker of malignant transformation of cells, and is closely related to the proliferation and invasion ability of tumor cells. It is expected to be a new marker for early diagnosis and prognosis of malignant tumors.