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RU486是一种强有力的抗孕酮、抗糖皮质激素药,并有轻微的抗雄激素作用。该药作用于下丘脑-垂体水平以及生殖系统(包括子宫内膜和宫颈),与孕酮竞争受体,可逆性地阻断孕酮的生物学作用。已证明该药可使妊娠宫颈扩张,但对非妊娠宫颈作用如何尚无人研究,作者对此做了研究。作者采用了随机双盲安慰剂对照试验的方法,对30例要求终止妊娠的早期妊娠妇女及30例要行宫颈扩张和诊刮术或腹腔镜绝育术的绝经前非妊娠妇
RU486 is a potent antiprogestin, anti-glucocorticoid and mild anti-androgenic effect. The drug acts on the hypothalamic-pituitary level and on the reproductive system (including the endometrium and cervix), competing with progesterone for receptors and reversibly blocking the biological effects of progesterone. The drug has been shown to cause cervical dilatation in pregnancy, but no one has studied on the role of the nonpregnant cervix. The authors studied this. The authors used a randomized, double-blind, placebo-controlled trial of 30 premenopausal women who required termination of pregnancy and 30 premenopausal women who underwent cervical dilatation and curettage or laparoscopic sterilization