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目前在正常机体状况下是难以找到致HFRS病模型的。本研究设计了一种人工干预方法,用经环磷酰胺预处理后的猕猴感染HFRSV,结果发生感染,引起病毒血症,产生抗体应答,并表现出了某些类似HFRS病人的症状。主要有肾脏损伤出现的蛋白尿、管型尿、氮血症、血钾增高和毛细血管中毒症状,伴有红细胞和血色素降低及血小板下降,在白细胞分类中出现了异形淋巴等血象改变,而且实验组4只感染猕猴中1只合并脑内出血等导致死亡,1只出现了后肢麻痹等神经症状。这种方法虽然人为地增加了干预因素,但动物出现了感染、发病,表现类似于人类HFRS,复制出了致病动物模型,为HFRS临床治疗、药物筛选提供了可选择的实验动物。
It is currently difficult to find a model of HFRS disease in normal body conditions. In this study, a manual intervention was designed to treat HFRSV infection with cyclophosphamide preconditioned rhesus monkeys. Infection resulted in viremia, antibody response, and symptoms of some HFRS-like patients. There are mainly proteinuria, tubular urine, azotemia, hyperkalemia and capillary poisoning symptoms associated with renal damage, accompanied by decreased red blood cells and hemoglobin and decreased platelets, abnormal blood lymphoid changes appear in the classification of leukocytes, and the experiment In Group 4, only one of the macaques infected with intracerebral hemorrhage resulted in death, and one developed neurological symptoms such as paralysis of the hind limb. Although this method artificially increased the intervention factor, but the animal appeared the infection, the morbidity, the performance is similar to the human HFRS, replicates the pathogenic animal model, has provided the selectable experimental animal for the HFRS clinical treatment, the medicine screening.