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目的:观察祛异康对子宫内膜异位症模型大鼠基质金属蛋白酶-2、7表达的影响,探讨祛异康治疗子宫内膜异位症的机制。方法:采用手术移植法建立大鼠子宫内膜异位症模型,随机分为对照组、模型组、丹那唑组、祛异康大、中、小剂量组。造模成功各组给药4周,免疫组化方法检测大鼠在位、异位内膜中MMP-2、MMP-7的表达。结果:模型组MMP-2及MMP-7的阳性表达率明显高于对照组及各治疗组(P<0.05);祛异康大、中剂量组异位内膜MMP-2、MMP-7的表达与模型组比较明显降低(P<0.05),与丹那唑组比较无明显差异(P>0.05)。结论:祛异康能明显抑制模型大鼠异位内膜的生长,其治疗机理可能是通过下调MMP-2,MMP-7在异位内膜组织的过度表达及酶活性,达到降低其侵袭、转移、种植的能力起到治疗目的。
Objective: To observe the effect of QuYankang on the expression of matrix metalloproteinase-2 and 7 in rat model of endometriosis and explore the mechanism of QuYankang in treating endometriosis. Methods: A rat model of endometriosis was established by surgical transplantation. The rats were randomly divided into control group, model group, danazol group, Qu Yi Kang Da, medium and low dose groups. The rats in each group were given the drug for 4 weeks successfully. The expression of MMP-2 and MMP-7 in eutopic and ectopic endometrium of rats was detected by immunohistochemistry. Results: The positive rates of MMP-2 and MMP-7 in the model group were significantly higher than those in the control group and each treatment group (P <0.05). The expression of MMP-2 and MMP-7 Compared with the model group, the expression was significantly decreased (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: Qu Yi Kang can significantly inhibit the growth of ectopic endometrium in model rats, and its therapeutic mechanism may be through down-regulating the overexpression of MMP-2 and MMP-7 in the ectopic endometrium and the activity of enzymes to reduce their invasion, Transfer, planting ability for therapeutic purposes.