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上皮细胞具有极性结构,可以形成各种组织和器官,上皮组织通过极性蛋白发挥功能,传递信号.极性蛋白构成和调控上皮组织结构的完整性,建立和维持细胞极性,调节紧密连接和黏附连接；极性蛋白是肿瘤抑制因子,可与原癌基因相互作用,破坏细胞极性,诱导肿瘤发生.上皮细胞极性机制可为临床治疗提供靶点.
极性蛋白调控肿瘤发生的分子机制
【摘 要】
：
上皮细胞具有极性结构,可以形成各种组织和器官,上皮组织通过极性蛋白发挥功能,传递信号.极性蛋白构成和调控上皮组织结构的完整性,建立和维持细胞极性,调节紧密连接和黏附连
【机 构】
：
第四军医大学西京医院肝胆胰脾外科
【出 处】
：
国际肿瘤学杂志
【发表日期】
：
2004年期
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