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目的探讨晚期胃肠道肿瘤正虚程度与外周血肿瘤缺氧相关蛋白之间的关系。方法普陀医院肿瘤科2012年4月1日到2013年4月10日IV期胃肠道肿瘤患者46例,以卡氏(Karnofsky Performance Status,KPS)评分、中医症候(气短、纳差、爪甲不荣)作为评价患者正虚指标,并根据正虚指标分别分组,采用酶联免疫吸附法检测患者血清中血管内皮生长因子(vascular endothelial growth factor,VEGF)、骨桥蛋白(osteopontin,OPN)、碳酸酐酶IX(carbonic anhydrase IX,CAIX)水平。结果经成组t检验,晚期胃肠道肿瘤患者KPS≤60分组与KPS>60分组比较,前者VEGF、OPN、CAIX水平分别是后者的1.75倍(P<0.05)、1.10倍(P>0.05)、1.68倍(P<0.05)。晚期胃肠道肿瘤具有气短、纳差、爪甲不荣症状患者外周血VEGF、OPN、CAIX水平均明显高于无上述症状患者(爪甲不荣组CAIX除外),其中以VEGF指标均有统计学意义(P<0.05)。结论晚期胃肠道肿瘤正虚程度与外周血缺氧相关蛋白VEGF、OPN、CAIX相关。
Objective To investigate the relationship between the degree of deficiency in advanced gastrointestinal tumors and hypoxia associated proteins in peripheral blood tumor. Methods Putuo Hospital oncology April 1, 2012 to April 10, 2013 46 patients with stage IV gastrointestinal cancer patients, Karnofsky Performance Status (KPS) score, TCM symptoms (shortness of breath, anorexia, claw Non-rating) were evaluated as positive index of patients, and were grouped according to the index of positive and negative. The serum levels of vascular endothelial growth factor (VEGF), osteopontin (OPN) Carbonic anhydrase IX (CAIX) levels. Results The results of group t test showed that the levels of VEGF, OPN and CAIX in patients with advanced gastrointestinal cancer were 1.75 times (P <0.05) and 1.10 times (P> 0.05) higher than those in KPS group ), 1.68 times (P <0.05). Gastrointestinal cancer patients with shortness of breath, anorexia, claw nail ailments in patients with peripheral blood VEGF, OPN, CAIX levels were significantly higher than those without these symptoms (claw Jiabu Rong group CAIX excluded), in which the VEGF indicators were statistics Significance (P <0.05). Conclusions The positive and negative degree of the late gastrointestinal cancer is related to the hypoxia related protein VEGF, OPN and CAIX in peripheral blood.