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目的了解类鼻疽伯克霍尔德菌败血症感染的特点和耐药性。方法收集2002年6月～2009年6月我院住院确诊的类鼻疽伯克霍尔德菌败血症感染株50例,采用CLSI推荐的纸片扩散法进行药敏试验。结果病例以农民多见占68%,接触疫水、免疫功能低下为易感因素,多伴有基础性疾病,误诊率高。类鼻疽伯克霍尔德菌对亚胺培南和美洛培南最敏感。结论类鼻疽病中以败血症多见,亚胺培南和美洛培南可作为治疗本病的首选用药。该菌对多种常用抗生素耐药率较高,加强对本病的认识程度,早期进行细菌培养确诊,及时选用有效的抗生素治疗具有重要意义。
Objective To understand the characteristics and drug resistance of Burkholderia pseudomallei infection. Methods Fifty patients with Burkholderia cepacia infection in our hospital from June 2002 to June 2009 were collected. Susceptibility testing was performed by the disk diffusion method recommended by CLSI. Results Most cases of peasants accounted for 68%, contact with water, immune dysfunction as predisposing factors, often accompanied by underlying diseases, misdiagnosis rate. Burkholderia pseudomallei is most sensitive to imipenem and meropenem. Conclusions Infectious diseases are more common in sepsis and imipenem and meropenem can be used as the first choice for the treatment of this disease. The bacteria resistant to a variety of commonly used antibiotics higher, to enhance awareness of the disease, the early diagnosis of bacterial culture, timely and effective use of antibiotic therapy is of great significance.