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环氧化酶(COX)是一种花生四烯酸代谢限速酶,其中一种同工酶环氧化酶2(COX-2)通过多种途径参与食管癌的发生、发展,并和预后密切相关。微血管及微淋巴管的生成在食管癌的生成和发展中起到了至关重要的作用,COX-2可能通过促进微血管及微淋巴管的生成参与了食管癌的发生与发展。本文就COX-2在食管癌中的表达及与食管癌组织中微血管及微淋巴管生成的关系予以综述。
Cyclooxygenase (COX) is a rate-limiting enzyme of arachidonic acid metabolism, in which one of the isoenzymes cyclooxygenase 2 (COX-2) is involved in the occurrence, development and prognosis of esophageal cancer through a variety of pathways closely related. Microvessel and lymphangiogenesis play a crucial role in the formation and development of esophageal cancer. COX-2 may be involved in the occurrence and development of esophageal cancer by promoting the formation of microvascular and lymphatic vessels. This article reviews the expression of COX-2 in esophageal cancer and its relationship with microvessel and lymphangiogenesis in esophageal cancer tissues.