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为探讨糖尿病大鼠低密度脂蛋白糖化率与动脉壁胶原含量变化的关系，将糖尿病大鼠并分为糖尿病组（ＤＭ），糖尿病氨基胍治疗组（ＡＧ）和对照组（Ｃ）。测定血糖（ＢＧ）、甘油三酯（ＴＧ）、胆固醇（ＴＣ）、低密度脂蛋白（ＬＣＬ）、糖化低密度脂蛋白（Ｇ－ＬＤＬ）及其糖化率（Ｋ）、糖化血红蛋白（ＨｂＡｌｃ）、动脉壁Ⅳ型胶原（ＣＩＶ）和Ⅲ型前胶原（ＰＣⅢ）。 ＤＭ组和ＡＧ组的ＢＧ水平高于Ｃ组（Ｐ＜ ０． ０１），但各组间的 ＴＧ、ＴＣ和ＬＤＬ水平无差异。ＤＭ组和 ＡＧ组的ＨｂＡｌＣ、和 Ｋ值显著高于 Ｃ组（ Ｐ＜ ０． ０１）。 ＤＭ组的动脉壁ＣＩＶ和ＰＣⅢ含量高于ＡＧ组和Ｃ组（ Ｐ＜０．０１）；Ｋ值与 ＣＩＶ和ＰＣⅢ含量呈正相关，（ｒ分别为０．８０６和０．８５１， Ｐ＜０．０１）。实验结果提示Ｇ－ＬＤＬ参与动脉壁的早期脂质沉积和胶原增加，是糖尿病动脉粥样硬化病变的重要促进因素之一。
To investigate the relationship between low density lipoprotein (LDL) saccharification rate and arterial wall collagen content in diabetic rats, diabetic rats were divided into diabetic group (DM), diabetic aminoguanidine (AG) group and control group (C). Blood glucose (BG), triglyceride (TG), cholesterol (TC), low density lipoprotein (LCL), glycosylated low density lipoprotein (G-LDL) and their saccharification rate (K), glycosylated hemoglobin Arterial wall type Ⅳ collagen (CIV) and type Ⅲ procollagen (PC Ⅲ). BG levels in DM group and AG group were higher than those in C group (P <0.01), but there was no difference in TG, TC and LDL between groups. The HbAlC and K values in DM group and AG group were significantly higher than those in C group (P <0.01). The contents of CIV and PCⅢ in arterial wall of DM group were higher than that of AG and C group (P <0.01). K value was positively correlated with CIV and PCⅢ (r = 0.806 and 0.851, P <0. 01). The experimental results suggest that G-LDL is involved in the early lipid deposition and collagen increase of the arterial wall, which is one of the important contributing factors of the diabetic atherosclerosis.