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目的研究2012-2014年哈励逊国际和平医院临床标本中分离出的真菌分布及耐药性变迁,给临床用药提供依据。方法采用法国梅里埃VITEK2-Compact微生物自动鉴定药敏仪进行真菌的鉴定和药敏实验。结果 2012-2014年共分离真菌菌株295株,白色念珠菌138株(占46.8%),热带念珠菌104株(占35.3%),光滑念珠菌37株(占12.5%),克柔念珠菌13株(占4.4%),其他真菌3株(占1%)。白色念珠菌、热带念珠菌及光滑念珠菌三种主要真菌对两性霉素B和伊曲康唑的耐药率均为0%,对5-氟胞嘧啶有较低的耐药率(≤13.3%)。白色念珠菌对酮康唑、氟康唑及5-氟胞嘧啶的耐药率有逐年增加趋势。结论白色念珠菌是我院真菌感染中最常见的病原菌,感染率逐年上升,耐药率越来越严重,今后应加强抗真菌药物的应用管理。
Objective To study the changes of fungal distribution and drug resistance isolated from clinical specimens of Harrison International Peace Hospital from 2012 to 2014, and provide basis for clinical use. Methods The identification and antimicrobial susceptibility test of fungi were carried out by the automatic identification instrument of VITEK2-Compact microorganism in France. Results A total of 295 strains of fungi, 138 strains of Candida albicans (46.8%), 104 strains of Candida tropicalis (35.3%), 37 strains of Candida glabrata (12.5%), Candida krusei 13 Strains (4.4%), three other fungi (1%). Candida albicans, Candida tropicalis and Candida glabrata were 0% resistant to amphotericin B and itraconazole, and had a lower resistance to 5-fluorocytosine (≤13.3 %). Candida albicans on ketoconazole, fluconazole and 5-fluorocytosine resistance rates have increased year by year. Conclusion Candida albicans is the most common pathogenic fungus in our hospital. The infection rate increases year by year and the drug resistance rate is getting more and more serious. In the future, the application management of antifungal drugs should be strengthened.