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目的探讨不同粒径的纳米硫化铅对雄性大鼠生殖能力的影响。方法将24只清洁级SD雄性大鼠随机分为4组,分为对照(生理盐水)组和15、35、75 nm纳米硫化铅染毒组,每组6只。采用灌胃方式进行染毒,染毒用量为10 ml/kg,每天1次,连续染毒8周。测定大鼠的精子存活率,并对睾丸进行病理学观察。结果与对照组相比,不同粒径纳米硫化铅染毒组大鼠的精子存活率均较低,差异有统计学意义(P<0.05);且随着纳米硫化铅粒径的增大,大鼠的精子存活率呈上升趋势。病理学观察结果显示,75 nm纳米硫化铅染毒组生精小管变化不明显,各级精母细胞略显减少;35 nm纳米硫化铅染毒组生精小管内各级精母细胞数量减少;15 nm纳米硫化铅染毒组生精小管萎缩呈空网状,管腔内生精细胞脱落坏死。结论纳米硫化铅可损伤大鼠睾丸组织,影响精子生成,具有雄性生殖毒性,且粒径越小毒性越大。
Objective To investigate the effect of nano-lead sulfide of different particle size on reproductive capacity of male rats. Methods Twenty-four male Sprague-Dawley rats were randomly divided into 4 groups, which were divided into control (normal saline) group and 15, 35, 75 nm nano-lead sulfide poisoning group, 6 rats in each group. Gavage by way of exposure, the dose of 10 ml / kg, 1 day, continuous exposure to 8 weeks. The sperm survival rate of rats was measured, and the testicular pathological observation. Results Compared with the control group, the sperm survival rate of rats exposed to nano-PbS was lower than that of the control group (P <0.05). With the increase of the particle size of lead Rat sperm survival rate is on the rise. The results of pathology showed that the changes of spermatids were not obvious in 75 nm nano-lead sulphate-treated groups, and the number of spermatids in all groups was slightly decreased. The numbers of spermatocytes in each level of spermatids in 35 nm nano- The seminiferous tubules of 15 nm Nano-PbS-exposed group were atrophied and empty, and the spermatogenic cells in the lumen were exfoliated and necrotic. Conclusion Nano-lead sulphide can damage rat testis tissue and affect spermatogenesis with male reproductive toxicity. The smaller the particle size, the greater toxicity.