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目的观察2型糖尿病(DM)患者的空腹血糖(FPG)水平变化与真胰岛素(TI)的相关性,有助于评估2型糖尿病患者的TI是否受血糖的影响及TI的真实水平。方法正常对照组100例。2型糖尿病组:本院住院患者200例,男123例,女77例,平均年龄57岁。将空腹血糖(FPG)浓度在6.0-10mmol/L之间的136例编为A组,FPG>10mmol/L的64例编为B组。正常对照组和2糖尿病组患者均于早晨8时空腹采静脉血3ml送检,分离血清,FPG采用全自动生化分析仪检测,TI采用化学发光免疫分析法(CLIA)定量检测。结果正常对照组TI浓度为(33.00±19.06)pmol/L;2型糖尿病患者TI浓度为(34.57±20.52)pmol/L;A组TI浓度为(36.00±24.58)pmol/L;B组TI浓度为(39.52±23.47)pmol/L;各组间进行统计学处理,无统计学意义(P>0.05)。对2型糖尿病组进行FPG和TI的相关性统计,其相关系数(r)=0.0055,回归方程:Y=35.999+0.037X。因此,FPG浓度与TI浓度呈正相关。结论2型糖尿病患者TI浓度随FPG浓度的上升而增高,两者之间呈正相关。说明2型DM患者空腹TI受血糖的影响,维持血糖稳定对2型DM患者有实际意义。
Objective To observe the relationship between fasting blood glucose (FPG) levels and true insulin (TI) in type 2 diabetic patients and to assess whether TI is affected by blood glucose and TI’s real level in type 2 diabetic patients. Methods 100 cases of normal control group. Type 2 diabetes group: 200 hospitalized patients, 123 males and 77 females, with an average age of 57 years. 136 cases with fasting blood glucose (FPG) concentration between 6.0-10mmol / L were classified as group A and 64 cases with FPG> 10mmol / L as group B. The normal control group and 2 diabetic patients were seized at 3ml in the morning of 8:00 AM, and serum was separated. The FPG was detected by automatic biochemical analyzer. TI was detected by chemiluminescence immunoassay (CLIA). Results The concentration of TI in normal control group was (33.00 ± 19.06) pmol / L; the level of TI in type 2 diabetic patients was (34.57 ± 20.52) pmol / L; the concentration of TI in group A was (36.00 ± 24.58) pmol / (39.52 ± 23.47) pmol / L respectively. There was no statistical significance between the two groups (P> 0.05). The correlation coefficient between FPG and TI in type 2 diabetic patients was (r) = 0.0055, and the regression equation was Y = 35.999 + 0.037X. Therefore, FPG concentration and TI concentration was positively correlated. Conclusion The concentration of TI in type 2 diabetic patients increases with the increase of FPG concentration, and there is a positive correlation between them. It shows that the fasting TI of type 2 diabetic patients is affected by blood glucose, and the maintenance of stable blood glucose has practical significance for patients with type 2 DM.