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色素上皮衍生因子(pigment epithelium-derived factor,PEDF)是丝氨酸蛋白酶抑制因子超基因家族的一员,显著的特点是其序列高度保守、分子结构独特。因其具有营养和保护神经、抗新生血管生成、促进肿瘤分化和凋亡等多种生物学功能而受到广泛关注与研究。大量研究表明PEDF抑制实体肿瘤血管生成功效显著,因此其抑制血管生成的功能尤为受到重视。同时PEDF也是近年来国外研究较多的肿瘤生长和转移抑制因子之一。如果将PEDF应用于肿瘤的防治中,笔者还需对其抗肿瘤的生物学效应有更深入的理解。因此笔者现就其生物化学、抗肿瘤表现等方面进行综述。
Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor supergene gene family, which is characterized by its highly conserved sequence and unique molecular structure. Because of its nutrition and neuroprotection, anti-angiogenesis, promote tumor differentiation and apoptosis and other biological functions and receive wide attention and research. A large number of studies have shown that PEDF inhibits solid tumor angiogenesis significant effect, so its inhibition of angiogenesis is particularly valued. At the same time, PEDF is one of the most important tumor growth and metastasis suppressors in recent years. If the application of PEDF in the prevention and treatment of cancer, I also need to have a more in-depth understanding of the biological effects of its anti-tumor. So I now on its biochemistry, anti-tumor performance and other aspects are reviewed.