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1978年我国首次报道棉酚具抗生殖作用之后,不少实验室证明棉酚能特异性地抑制培养细胞的 DNA合成,能降低植物凝血素刺激人外周淋巴细胞的分裂指数,还能抑制多种酶(包括各种脱氢酶、ATP 酶及其它参与线粒体氧化磷酸化酶)的活性.因此,本文作者认为棉酚可能是一种潜在的抗肿瘤药物.作者通过三种小鼠肿瘤模型研究了棉酚的抗瘤作用.先给小鼠接种10~5个小鼠乳腺腺癌 Ca755细胞,两天(48hr)后一次性注射最适剂量(0.5mg/小鼠)棉酚.结果表明注射棉酚的小鼠中有66%的小鼠体内肿瘤细胞不生长,其余34%死於棉酚药物中毒.用超
After the first report of the anti-reproductive effect of gossypol in China in 1978, many laboratories have demonstrated that gossypol can specifically inhibit the DNA synthesis of cultured cells, reduce the mitogenic index of phytocoagulin stimulated human peripheral lymphocytes, and can also inhibit multiple Enzymes (including various dehydrogenases, ATPases, and other enzymes involved in mitochondrial oxidative phosphorylase activity). Therefore, the authors believe that gossypol may be a potential antitumor drug. The authors studied three mouse tumor models. Anti-tumor effect of gossypol. Mice were first inoculated with 10~5 mouse mammary adenocarcinoma Ca755 cells. The optimal dose (0.5 mg/mouse) of gossypol was injected at one time after two days (48 hrs). The results showed that the mice were injected with cotton. In 66% of the phenol mice, tumor cells did not grow, and the remaining 34% died of gossypol poisoning.