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目的探讨妊娠期妇女生殖道大肠埃希菌感染对妊娠不良结局的影响。方法回顾性分析2011年1月至2013年12月在石家庄市第四医院住院孕产妇共2 053例,进行阴道分泌物细菌培养,对大肠埃希菌培养阳性组与正常对照组的妊娠结局进行分析,以探讨妊娠合并生殖道大肠埃希菌感染与围产期并发症的关系。结果在2 053例围产期妇女中,无致病菌组(对照组)为1230例,大肠埃希菌培养阳性组(感染组)为103例,总患病率为5.02%。感染组与对照组的绒毛膜羊膜炎的发生率分别为78.64%、12.20%(P<0.01),产褥感染率分别为24.27%、3.41%(P<0.01),新生儿黄疸的发生率58.25%、12.36%(P<0.01),胎膜早破率分别为11.65%、10.57%(P>0.05),早产率分别为3.88%、3.09%(P>0.05),胎儿窘迫的发生率2.91%、2.76%(P>0.05),低体重儿的发生率1.94%、2.03%(P>0.05)。结论妊娠期妇女生殖道大肠埃希菌感染与绒毛膜羊膜炎、产褥感染及新生儿黄疸的发生相关,孕期及早发现、诊断、治疗妊娠期妇女生殖道大肠埃希菌感染是有重要意义。
Objective To investigate the effect of genital tract Escherichia coli infection in pregnant women during pregnancy on adverse outcomes of pregnancy. Methods A retrospective analysis of 2 053 in-hospital pregnant women in Shijiazhuang Fourth Hospital from January 2011 to December 2013 was conducted for bacterial culture of vaginal secretions. The pregnancy outcome of positive control group and Escherichia coli culture group Analysis to explore the relationship between pregnancy complicated with Escherichia coli infection and perinatal complications. Results Among 2 053 perinatal women, there were 1230 non-pathogenic bacteria in the control group and 103 in the positive control group (infection group), with a total prevalence of 5.02%. The incidence of chorioamnionitis was 78.64% and 12.20% respectively (P <0.01), and the rate of puerperal infection was 24.27% and 3.41% respectively (P <0.01). The incidence of neonatal jaundice was 58.25 The rates of premature rupture were 11.65%, 10.57% (P> 0.05), premature rupture rate was 3.88%, 3.09% (P> 0.05) respectively. The incidence of fetal distress was 2.91% , 2.76% (P> 0.05). The incidence of low birth weight children was 1.94% and 2.03% (P> 0.05). Conclusion The genital tract infection of Escherichia coli in women during pregnancy is related to the occurrence of chorioamnionitis, puerperal infection and neonatal jaundice. It is of great significance to detect, diagnose and treat Escherichia coli in reproductive tract during pregnancy.