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观察外源性降钙素基因相关肽（CGRP）对血栓形成后大鼠腹主动脉环舒张效应以及CGRP拮抗剂CGRP（8－37）对CGRP效应的影响．方法：利用离体血管灌流技术．结果：CGRP对血栓形成的大鼠腹主动脉舒张作用增强，在10-10～10-6mol／L范围内，CGRP对血栓组、肝素抗凝组和正常对照组大鼠腹主动脉均有舒张作用，并呈现浓度依赖性，其中对血栓组的舒张作用最为显著，最大舒张百分数（Rmax）为（56．32±10．92）％．CGRP（8－37）可拮抗正常及血栓组腹主动脉内源性CGRP的作用．结论：提示CGRP可能是血管系统中的非胆碱能和非肾上腺素能递质．血栓形成局部血管壁CGRP1受体密度和（或）CGRP纤维分布可能改变．
To observe the effects of exogenous CGRP on the aortic ring relaxation after thrombosis and the effects of CGRP antagonist CGRP (8-37) on CGRP. Methods: Using ex vivo vascular perfusion technique. Results: CGRP enhanced the dilation of abdominal aorta in thrombus-induced rats. CGRP was relieved in thrombus group, heparin anticoagulation group and normal control rats in the range of 10-10 ~ 10-6mol / L And showed a concentration-dependent manner. Among them, the most obvious relaxation effect was on thrombus group, the maximum relaxation percentage (Rmax) was (56.32 ± 10.92)%. CGRP (8-37) antagonizes the role of endogenous CGRP in the normal and thrombosed abdominal aorta. Conclusion: It is suggested that CGRP may be non-cholinergic and non-adrenergic neurotransmitter in the vascular system. Thrombosis Local vascular wall CGRP1 receptor density and / or CGRP fiber distribution may change.