研究表明脑缺血损伤是一种损伤级联反应,即兴奋性氨基酸毒性释放,梗死区周围去极化,程序性细胞死亡和炎性反应~([1]),其中炎性级联反应在急性缺血性卒中(acute ischemic stroke,AIS)的进展中起至关重要的作用~([2])。脑缺血可诱导多种促炎介质的表达,如细胞因子,包括肿瘤坏死因子TNF-α、白介素IL-1β、IL-10和黏附分子(ICAM)等,在中枢神经系统炎性反应的扩散和持续方面起着重要的作用~([3])。急 Studies have shown that cerebral ischemia injury is a cascade of injury, that is, the release of excitatory amino acids, depolarization around the infarct zone, programmed cell death and inflammatory response ([1]), in which inflammatory cascade in Acute ischemic stroke (acute ischemic stroke, AIS) play a crucial role in the progress of ~ ([2]). Cerebral ischemia can induce the expression of a variety of proinflammatory mediators, such as cytokines, including TNF-α, IL-1β, IL-10 and ICAM, in the proliferation of central nervous system inflammatory reaction And continuing aspects play an important role ~ ([3]). anxious