【摘 要】
：
目的观察前列地尔注射液对急性脑梗死(acute cerebral infarction,ACI)患者的临床疗效及对患者脑灌注水平的影响。方法 83例ACI患者随机分为前列地尔组(n=43)和常规治疗组(n=
【机 构】
：
中南大学湘雅附属海口医院放射科,中南大学湘雅附属海口医院神经内科,
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目的观察前列地尔注射液对急性脑梗死(acute cerebral infarction,ACI)患者的临床疗效及对患者脑灌注水平的影响。方法 83例ACI患者随机分为前列地尔组(n=43)和常规治疗组(n=40)及健康对照组(n=40)。采用全脑磁共振灌注成像(PWI),观察患者在治疗后48h,7d的脑灌注水平,并在治疗后7d进行临床疗效的判定。结果两组患者治疗7d后,前列地尔组在相对脑血流量(rCBF),相对脑血容积(rCBV),均较常规治疗组显著增加(P﹤0.01)。结论前列地尔注射液可能通过改善脑灌注水平发挥治疗ACI的有效性。
Objective To observe the clinical efficacy of alprostadil injection in patients with acute cerebral infarction (ACI) and its effect on cerebral perfusion. Methods 83 patients with ACI were randomly divided into alprostadil group (n = 43) and conventional treatment group (n = 40) and healthy control group (n = 40). Whole-brain magnetic resonance perfusion imaging (PWI) was used to observe the cerebral perfusion level at 48h and 7d after treatment. The clinical efficacy was evaluated 7 days after treatment. Results After 7 days treatment, the relative cerebral blood flow (rCBF) and relative cerebral blood volume (rCBV) in the alprostadil group were significantly increased (P <0.01) compared with those in the conventional treatment group. Conclusions Alprostadil injection may improve the effectiveness of ACI by improving cerebral perfusion.
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