【摘 要】
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Adult endogenous neurogenesis was first defined as the genera-tion of neurons and glia cells in the central nervous system(CNS);it was subsequently referred to as the activation of endogenous neural stem cells,and ultimately limited to the generation of n
【机 构】
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Department of Neurobiology,School of Basic Medicine,Capital Medical University,Beijing 100069,China;
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Adult endogenous neurogenesis was first defined as the genera-tion of neurons and glia cells in the central nervous system(CNS);it was subsequently referred to as the activation of endogenous neural stem cells,and ultimately limited to the generation of new neurons[1].The research team led by Xiaoguang Li enriched this concept in 2015:Endogenous neural stem cells in the adult CNS can be activated,recruited,and migrated to the injured area,where these stem cells further differentiate into mature neurons.The new neurons may form a functional neural circuit with host neurons,resulting in function recovery[2].The main body of endogenous neurogenesis is neural stem cells,they can be self-renewable and multipotent,means that they can replicate and can produce different mature cell types.Neural stem cells in the central canal and/or its subregion of the spinal cord are activated.Most of them proliferate and differentiate into astrocytes(which are involved in scar formation)and a small number of oligodendro-cytes,with almost no new neurons[3].
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