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目的总结活性氧在肝脏缺血再灌注损伤中的发病机理及活性氧防治的最新研究进展。方法通过对CNKI、Pub Med等数据库文献进行检索,就活性氧在肝脏缺血再灌注损伤中的产生、损伤机理以及对近年来在活性氧防治方面的研究进展进行综述。结果在肝脏缺血再灌注损伤中,多形核白细胞、Kupffer细胞、线粒体以及肝组织中的酶产生大量的活性氧。活性氧主要通过破坏细胞膜上寡糖链中的糖分子、体内的不饱和脂肪酸、蛋白质分子、遗传物质、线粒体等导致细胞损伤甚至死亡。目前主要的防治方法为利用酶、维生素、中草药等清除活性氧,减轻肝脏缺血再灌注损伤。结论目前关于活性氧在肝脏缺血再灌注损伤中的研究取得了重要进展,针对活性氧对肝脏造成的损伤也提出了多种可行的防治方法,但要应用于临床还有待进一步深入研究。
Objective To summarize the pathogenesis of reactive oxygen species (ROS) during hepatic ischemia-reperfusion injury and the latest research progress of active oxygen control. Methods The databases of CNKI and Pub Med were searched for the generation and injury mechanism of reactive oxygen species (ROS) during liver ischemia-reperfusion injury and the research progress of reactive oxygen species control in recent years. Results In liver ischemia-reperfusion injury, enzymes in polymorphonuclear leukocytes, Kupffer cells, mitochondria, and liver tissue produce large amounts of reactive oxygen species. Active oxygen mainly through the destruction of cell membrane sugar molecules in the oligosaccharide chain, the body of unsaturated fatty acids, protein molecules, genetic material, mitochondria and other cell damage caused or even death. At present, the main prevention and treatment method is to use enzymes, vitamins, herbs and the like to remove reactive oxygen species and reduce liver ischemia-reperfusion injury. Conclusion At present, important progress has been made in the research of reactive oxygen species (ROS) in liver ischemia-reperfusion injury. Many feasible prevention and cure methods have also been proposed for the damage caused by reactive oxygen species in the liver. However, further research is needed to be applied in clinic.