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目的：探讨持续小剂量窦内接触性溶栓治疗重症颅内静脉窦血栓形成的疗效与安全性。方法对照组患者采用经典方法行血管内治疗，行持续小剂量给药窦内接触性溶栓治疗。结果观察组总有效率为92.3%，对照组总有效率为76.9%，组间比较有统计学意义（P<0.05）。结论持续小剂量窦内接触性溶栓治疗重症颅内静脉窦血栓形成临床疗效满意且安全性高，值得进一步推广应用。“,”Objective To investigate the continuous low-dose treatment of severe sinus contact thrombolysis intracranial venous sinus thrombosis ef icacy and safety. Method The control group were treated with endovascular treatment of the classical method, the line continued smal doses sinus contact thrombolysis. Results The total ef ective rate was 92.3%in the control group, the total ef ective rate was 76.9%, between the two groups was statistical y significant (P<0.05). Conclusion continuous low-dose treatment of severe sinus contact thrombolysis intracranial venous sinus thrombosis satisfactory clinical ef icacy and safety, deserve further promotion.