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目的 :观察和分析测定子痫前期(PE)及子痫患者凝血指标和肿瘤坏死因子-α(TNF-α)的临床意义。方法 :选取80例健康孕妇作为对照组,选取80例轻度PE患者作为轻度组,选取80例重度PE患者和子痫患者作为重度组,并根据是否合并危重并发症将重症组患者分为有并发症组(34例)和无并发症组(46例)。对所有研究对象的血浆纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、D-二聚体(D-D)、TNF-α水平进行检测和比较。结果 :重度组患者或轻度组患者的FIB水平和TT水平均显著高于对照组,重度组患者的APTT水平和PT水平均显著低于轻度组或对照组,重度组的D-D水平和TNF-α水平均显著高于轻度组,轻度组患者的D-D水平和TNF-α水平均显著高于对照组,以上差异均有统计学意义;有并发症组患者的血浆FIB水平、D-D水平、TNF-α水平均显著高于无并发症组;PE患者的TNF-α水平与D-D水平具有相关关系,FIB水平与D-D水平具有相关关系。结论 :PE患者体内存在着血液高凝状态和过度炎症反应,其程度与病情的严重程度和并发症的发生风险具有相关性,可作为预测PE发病、病情进展和并发症发生风险的辅助指标。
Objective: To observe and analyze the clinical significance of coagulation index and tumor necrosis factor-α (TNF-α) in patients with preeclampsia (PE) and eclampsia. Methods: Eighty healthy women with mild PE were selected as the mild group. Eighty patients with severe PE and eclampsia were selected as the severe group. The patients with severe disease were divided into Complication group (34 cases) and no complications group (46 cases). Plasma fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), D-dimer The level of detection and comparison. Results: The levels of FIB and TT in patients with severe or mild were significantly higher than those in control group. The levels of APTT and PT in severe patients were significantly lower than those in mild patients or controls. The levels of DD and TNF -α levels were significantly higher than the mild group, mild group of patients with DD levels and TNF-α levels were significantly higher than the control group, the above differences were statistically significant; with complications of patients with plasma FIB levels, DD levels , TNF-α levels were significantly higher than those without complications; TNF-α levels in PE patients and DD levels have a correlation, FIB levels and DD levels have a correlation. Conclusion: The hypercoagulable state and hyperinflammatory state in PE patients are related to the severity of the disease and the risk of complication. It can be used as a supplementary indicator to predict the onset of PE, the progression of the disease and the risk of complication.