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正常晶体内含有高浓度的还原型谷胱甘肽(以下简称GSH),可以保护晶体免受氧化作用而致白内障。在各种类型的白内障晶体中,GSH含量明显降低,一部分被氧化成为氧化型谷胱甘肽(简称GSSG),另一部分被结合到晶体蛋白上去形成混合型二硫键。谷胱甘肽还原酶(简称GR)可以使GSSG还原成为GSH,并能使谷胱甘肽从与蛋白结合的状态下释放出来。已经发现白内障晶体内这种酶的活性是降低的。核黄素是黄素腺嘌呤二核苷酸(简称FAD)的前体,而FAD又是GR必需的辅酶。因此,核黄素的缺乏与GR活性降低有密切关系。一些研究结果表明,核黄素缺乏与白内障的
Normal crystals contain high concentrations of reduced glutathione (hereinafter referred to as GSH), can protect the crystal from oxidation caused by cataracts. In various types of cataract crystals, the content of GSH is significantly reduced, one part is oxidized to oxidized glutathione (GSSG for short), the other part is bound to the crystal protein to form a mixed type disulfide bond. Glutathione reductase (GR) can reduce GSSG to GSH and release glutathione from protein-bound state. It has been found that the activity of this enzyme is reduced in cataract crystals. Riboflavin is a precursor of flavin adenine dinucleotide (FAD), which in turn is a coenzyme necessary for GR. Therefore, the lack of riboflavin and GR activity is closely related. Some studies have shown that riboflavin deficiency and cataract