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【目的】检测以呕吐为主要表现的婴儿血清食物特异性IgG,以探讨牛奶不耐受与呕吐的关系。【方法】收集2008年9月~2010年2月在唐都医院儿科门诊及住院的32例3月~1岁婴儿,全部满足下例条件:1)主要症状除频繁呕吐外,部分伴腹泻、血便、湿疹、生长缓慢;2)上消化道内镜提示胃、十二指肠有粘膜病变;3)食物不耐受检测对一种或一种以上食物蛋白不耐受;4)食物归避试验或激发试验阳性;其中男20例,女12例;对研究对象进行血常规、24 h食管PH值监测、胃镜检查、食物不耐受检测、食物归避试验;【结果】食物特异性IgG检测对食物不耐受引起之婴儿呕吐的病因诊断有积极临床意义,特别注意胃镜下黏膜糜烂或十二指肠增生为主的呕吐婴儿,应考虑完善食物不耐受检测,以免延误诊断和治疗。【结论】食物蛋白过敏是引起婴儿呕吐的原因之一,尤其是对频繁呕吐患儿治疗效果不佳时应考虑食物过敏。
【Objective】 To detect the serum-specific IgG of infant with vomiting as the main manifestation to investigate the relationship between milk intolerance and vomiting. 【Methods】 Thirty-two infants aged 3 months to 1 year old were selected from pediatric outpatients and hospitalized in Tangdu Hospital from September 2008 to February 2010, and all the following conditions were met: 1) The main symptoms except some frequent vomiting were diarrhea, Bloody stool, eczema, slow growth; 2) upper gastrointestinal endoscopy prompted gastric and duodenal mucosal lesions; 3) food intolerance test on one or more food intolerance; 4) food to avoid The test or challenge test was positive. There were 20 males and 12 females. Blood routine, 24 h esophageal pH monitoring, gastroscopy, food intolerance test and food evasion test were conducted. 【Results】 Food-specific IgG Detection of food intolerance caused by the etiological diagnosis of vomiting has a positive clinical significance, with particular attention to endoscopic mucosal erosion or duodenal vomiting mainly infants, should consider improving food intolerance testing, so as not to delay the diagnosis and treatment . 【Conclusion】 Food protein allergy is one of the causes of vomiting in infants, especially food allergy should be considered when the curative effect of children with frequent vomiting is not good.