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体外实验表明 ,薯蓣提取物 (DE)、三七皂甙 (PNS)和灯盏素 (EBF) 3种物质中 ,除了DE与EBF的伍用对复钙时间和TT有明显的延长作用外 (P <0 0 5 ) ,所有的单用和两两伍用对 2指标均无显著影响 ,但三者合用对两指标均产生显著的延长 (P <0 0 5 ,P <0 0 1) ;单用、两两伍用和三者合用均能延长PT、APTT ,且各药呈剂量依赖关系 ,三者的合用产生增值效应 ;正交实验表明 ,三者的最适配伍为 :PNS :EBF :DE =0 75 :0 75 :0 2 5 ,对PT影响最大的因素是EBF ,而APTT的是PNS。
In vitro experiments showed that among the three substances of Dioscorea bulbifera extract (DE), Panax notoginseng (PNS) and Erigeron (EBF), except for DE and EBF, their recalcification time and TT were significantly prolonged (P < 0 0 5 ) , all single use and double use have no significant effect on the 2 indicators, but the three combined use have a significant extension of both indicators (P <0 05, P <0 01); The combination of the two drugs and the three drugs can prolong PT and APTT, and each drug is dose-dependent. The combination of the three has a value-added effect. Orthogonal experiments show that the most suitable for the three is: PNS:EBF: DE =0 75 : 0 75 : 0 2 5 , the factor that has the most influence on PT is EBF, while APTT is PNS.