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近年来,蛋白C愈来愈引起人们的注意,不少作者已将其从人血浆和牛血浆中分离出来。它是一种丝氨酸蛋白酶原,其合成需维生素K。象血浆中依赖维生素K的凝血因子一样,蛋白C同样含有许多γ-羧基谷氨酸残基,但与凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ不同,激活的蛋白C没有促凝血效应。 50年代起,由于分析凝血活酶生成试验中所生成的活性不稳定的原因,不少作者描述并研究了存在于血浆中的抑制凝血活酶的成份,由于这种抗凝血活酶作用在凝血期间加强,并且血清中的活力大于血浆,而口服抗凝剂的患者血清中的这种活力低于血浆中者,因而很多
In recent years, protein C has attracted more and more attention, and many authors have isolated it from human plasma and bovine plasma. It is a serine protease, and its synthesis requires vitamin K. Like plasma-dependent coagulation factors that depend on vitamin K, protein C also contains many gamma-carboxyglutamic acid residues, but unlike coagulation factors II, VII, IX, and X, activated protein C has no procoagulant effect. Since the 1950s, due to the instability of the activity generated in the analysis of thromboplastin generation assays, many authors described and studied the inhibitory components of thromboplastin present in plasma because of the action of this anticoagulant enzyme. The blood coagulation is intensified, and the activity in the serum is greater than that in the plasma. However, in patients with oral anticoagulants, the activity in the serum is lower than that in the plasma, and thus many