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AIM: To study the potential role of dependence statuson CB_1-mediated blockade of ethanol self-administra-tion. METHODS: We examined the effects of thecannabinoid antagonist SR141716A (0, 0.03, 0.3,and 3 mg/kg) on pperant ethanol (10 ％ v/v) self-administration in male Wistar rats that were madeethanol-dependent by chronic (14 d ) exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS: Dependent animalsresponded more for ethanol than did air controlnondependent tats. The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.
AIM: To study the potential role of dependence statuson CB_1-mediated blockade of ethanol self-administra tion. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg / kg) on pperant ethanol % V / v) self-administration in male Wistar rats that were madehanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. RESULTS: Dependent animalsresponded more for ethanol than did air controlnondependent tats. acute administration of a 3mg / kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.