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目的 :总结平阳霉素 (PYM)、地塞米松 (DXM)和鱼肝油酸钠 (SM)三药联合注射治疗颌面部海绵状血管瘤的疗效及其优点。 方法 :收集 1996年 9月至 1998年 9月 ,用 PYM、DXM、SM联合注射治疗颌面部海绵状血管瘤115例 (15 6个瘤体 ) ,男性 5 0例 ,女性 6 5例 ,男女之比为 1∶ 1.3;年龄 4个月～ 45岁。瘤体位于颌面部 73例(6 3.48% ) ,口腔内 42例 (36 .5 2 % )。瘤体范围最小 1cm× 1cm ,最大 5 cm× 8cm。治疗方法 :用 DXM 5 mg/ 1ml配 PYM 8mg加 1%普鲁卡因注射液 4m l,按每 1cm× 1cm的瘤体内注射 1m l混合药液 ,再按相对大剂量鱼肝油酸钠注射的方法酌情注射鱼肝油酸钠。 5～ 7天注射 1次 ,3～ 5次为一个疗程。观察 1～ 2个月 ,未愈者可重复联合治疗。 结果 :经 6～ 2 4个月随访 ,治愈 81例 (70 .43% ) ,基本治愈 30例 (2 6 .0 9% ) ,好转 4例 (3.48% )。治愈和基本治愈率为 96 .5 2 % ,有效率为 10 0 %。 结论 :PYM、DXM、SM联合注射治疗颌面部海绵状血管瘤 ,具有疗程短、疗效高、不良反应小等优点 ,是一种安全、可靠、简便、易行 ,较为理想的方法。
OBJECTIVE: To summarize the curative effect and advantages of combination of PYM, DXM and SM in the treatment of maxillofacial cavernous hemangioma. Methods: From September 1996 to September 1998, 115 cases (15 6 tumors) of maxillofacial cavernous hemangiomas were treated with PYM, DXM and SM, 50 males and 65 females, male and female The ratio of 1: 1.3; age 4 months to 45 years old. The tumor was located in maxillofacial region in 73 cases (6 3.48%) and in oral cavity in 42 cases (36.52%). The smallest tumor size 1cm × 1cm, the largest 5 cm × 8cm. Treatment: DXM 5 mg / 1ml with PYM 8mg plus 1% procaine injection 4ml, according to each 1cm × 1cm tumor injections 1m l mixed liquid, and then a relatively large dose of sodium morrhuate injection Injection of cod liver oil as appropriate. 5 to 7 days injection 1, 3 to 5 times for a course of treatment. Observation of 1 to 2 months, healer can be repeated combination therapy. Results: After 6 to 24 months follow-up, 81 cases (70.43%) were cured, 30 cases (26.90%) were cured and 4 cases (3.48%) were cured. The cure rate and the basic cure rate were 96.52% and the effective rate was 100%. Conclusion: The combination of PYM, DXM and SM in the treatment of maxillofacial cavernous hemangioma has the advantages of short course of treatment, high curative effect and small adverse reaction. It is a safe, reliable, simple, easy and feasible method.