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目的探讨宫颈环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)的疗效。方法 180例宫颈上皮内瘤变患者作为研究对象,检查所有患者手术治疗前后的平均人乳头瘤病毒-DNA(HPV-DNA)负荷量。结果 LEEP术治疗前,CINⅠ、Ⅱ、Ⅲ级患者平均HPV-DNA负荷量分别为(540.6±743.2)pg/ml、(424.5±577.4)pg/ml、(513.7±641.6)pg/ml,手术治疗后分别为(73.3±326.8)pg/ml、(43.5±217.0)pg/ml、(26.4±133.4)pg/ml,术后平均HPV-DNA负荷量明显低于术前,对比差异具有统计学意义(P<0.05)。结论宫颈环形电切术治疗宫颈上皮内瘤变的疗效显著,具有非常积极的临床应用价值。
Objective To investigate the efficacy of cervical ring excision (LEEP) in the treatment of cervical intraepithelial neoplasia (CIN). Methods One hundred and eighty patients with cervical intraepithelial neoplasia were enrolled in this study. The average HPV DNA load of all patients before and after surgery was examined. Results The average HPV-DNA load in patients with CINⅠ, Ⅱ and Ⅲ before operation was (540.6 ± 743.2) pg / ml, (424.5 ± 577.4) pg / ml and (513.7 ± 641.6) pg / (73.3 ± 326.8) pg / ml, (43.5 ± 217.0) pg / ml and (26.4 ± 133.4) pg / ml respectively). The average postoperative load of HPV-DNA was significantly lower than that before operation, the difference was statistically significant (P <0.05). Conclusion Cervical ring resection of cervical intraepithelial neoplasia has a significant effect, with very positive clinical value.