目的探讨自动过滤取样模式对硝苯地平缓释片(I)释放度测定的干扰。方法采用溶出度测定法第二法装置,分别手工取样滤膜过滤和自动取样器滤芯过滤,测定硝苯地平缓释片(I)的释放度。结果通过两种过滤模式及回收率的测定显示,自动过滤取样装置对硝苯地平(I)有吸附作用。结论药品测定溶出度或释放度时,应先考察溶出度测定仪的自动取样装置对其是否有吸附作用,否则影响测定结果。 Objective To investigate the interference of the automatic filtration sampling mode on the determination of release of nifedipine sustained-release tablets (I). Methods The dissolution method was used to measure the release of nifedipine sustained-release tablets (I) by the second-hand method of dissolution assay, filtration by manual sampling and filtration by automatic sampler respectively. Results The results of the two filtration modes and recovery showed that the automatic filtration sampling device had an adsorption effect on nifedipine (I). Conclusion Dissolution or dissolution of the drug should be investigated before the dissolution of the automatic measuring device for its adsorption device, otherwise it will affect the measurement results.