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AIM:To determine the prevalence of antralization at theedge of proximal gastric ulcers,and the effect of H.pylorieradication on the mucosal appearances.METHODS:Biopsies were taken from the antrum,bodyand the ulcer edge of patients with benign proximal gastriculcers before and one year after treatment.Gastric mucosawas classified as antral,transitional or body type.H.pyloripositive patients received either triple therapy,or omeprazole.RESULTS:Patients with index ulcers in the incisura,bodyor fundus (n=116) were analyzed.Antral-type mucosa wasmore prevalent at the ulcer edge in H.pylori-positive patientsthan H.pylori-negative patients (93 % vs 60 %,0R=8.95,95 %CI:2.47-32.4,P=-0.001).At one year,there was asignificant reduction in the prevalence of antralization (from93 % to 61%,P=-0.004) at the ulcer edge in patients withH.pyloribeing eradicated.However,there was no differencein the prevalence of antralization at the ulcer edge in thosewith persistent infection.CONCLUSION:H.pylori infection is associated withantralization at the edge of proximal gastric ulcers,whichmay be reversible in some patients after eradication of theinfection.
AIM: To determine the prevalence of antralization at theedge of proximal gastric ulcers, and the effect of H. pylorieradication on the mucosal appearances. METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosawas classified as antral, transitional or body type. H. pyloripositive patients received either triple therapy, or omeprazole .RESULTS: Patients with index ulcers in the incisura, bodyor fundus (n = 116) were analyzed. wasmore prevalent at the ulcer edge in H. pylori-positive patientsthan H. pylori-negative patients (93% vs 60%, OR = 8.95, 95% CI: 2.47-32.4, P = -0.001) asignificant reduction in the prevalence of antralization (from93% to 61%, P = -0.004) at the ulcer edge in patients with H.pyloribeing eradicated. Home, there was no differencein the prevalence of antralization at the ulcer edge among thosewith persistent infections .CONCLUSION : H.pylori infect ion is associated withantralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.