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长期以来,肾小球疾病的易感性和(或)预后与遗传因素(如HLA)间的关系,一直是肾脏病学界广泛关注的问题。近年来随着分子生物学等研究手段的成熟和深入,一些研究结果显示某些基因多态性,如血管紧张素转换酶(ACE)基因、白细胞介素-1受体拮抗剂基因、粘附分子基因、肿瘤坏死因子-α(TNF-α)基因等多态性与某些肾脏疾病的严重性、预后和(或)易感性明显相关,探讨两者的关系已成为肾脏病领域中新的研究热点。这对于阐明疾病发病机理,更正确判断预
For a long time, the relationship between the susceptibility and / or prognosis of glomerular diseases and genetic factors (such as HLA) has been a widespread concern in the nephrology community. In recent years, as molecular biology and other research methods mature and deepen, some studies have shown that some genetic polymorphisms, such as angiotensin converting enzyme (ACE) gene, interleukin-1 receptor antagonist gene, adhesion Genetic polymorphisms such as molecular genes and tumor necrosis factor-α (TNF-α) are significantly associated with the severity, prognosis and / or susceptibility of some renal diseases, and the relationship between these two genes has become new in the field of kidney disease Research hot spots. This is to clarify the pathogenesis of the disease, a more correct judgment