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本文报导了7例急性白血病,误为急性淋巴细胞性白血病(以下简称急淋),因其原始细胞类似原淋巴细胞的形态,但经细胞遗传学研究均有pb′染色体,故提示为未发现慢性期的慢粒急化病例。初诊时髓象见到大量原始细胞,这些细胞核浆比例较高,核的结构比一般原始粒细胞稍粗,胞浆无颗粒,可见成熟淋巴及幼淋巴样的细胞,个别病例中少数原始细胞胞浆较丰富,染暗蓝色并有空泡,类似非洲淋巴瘤中所见者。但有4例发现粒细胞系列有异常——MGG染色及苏丹黑染色显示成熟粒细胞颗粒减少,部分细胞有Pelger-Huet异常,还可见到原单核样细胞,说明粒细胞系列受到波及,这在一般急淋的髓象中是不见的。此外,7例中3例苏丹黑染色阴性,另1例PAS染色中还见到阳性的小块物质。
This article reports seven cases of acute leukemia, mistaken for acute lymphoblastic leukemia (hereinafter referred to as acute lymphoblastic), because of its primitive cells similar to the original form of lymphocytes, but by cytogenetic studies have pb ’chromosome, suggesting that no discovery Chronic acute CML cases. When the first visit to see a large number of medullary primitive cells, a higher proportion of these cells nuclear plasma, nuclear structure than the average primary granulocytes slightly thicker, cytoplasmic no particles, showing mature lymphocytes and lymphoid cells, in some cases a small number of primitive cells Pulp more rich, stained dark blue and empty bubble, similar to those seen in African lymphoma. However, in 4 cases, there were abnormalities in the granulocyte series. MGG staining and Sudan staining showed that the number of mature granulocytes decreased, some of the cells had abnormalities of Pelger-Huet, and the original mononuclear cells were also found, which indicated that the granulocyte series were affected General acute lymphoid medulla is missing. In addition, three of the seven cases were negative for Sudan staining and the other positive for PAS staining.