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随着外科手术、放化疗及中西医结合治疗的发展,肿瘤患者生存时间明显延长,但是恶性肿瘤对人类健康的严重威胁仍未得到有效控制。要想提高肿瘤治疗疗效,只有从肿瘤发生发展的机制着手,才能取得新的突破性进展。细胞活性受外部信号控制,细胞信号转导异常可导致恶性肿瘤快速增殖、无限生长,因此,信号转导通路已成为抗肿瘤药物研究的新靶点。中药治疗肿瘤有着悠久历史,随着分子生物学、免疫学、中药药理学等技术的进步,中药及其有效成分通过调控信号转导通路实现对肿瘤的防治作用已成为近年抗肿瘤
With the development of surgery, radiotherapy and chemotherapy and the combination of traditional Chinese and Western medicine, the survival time of patients with cancer is significantly longer. However, the serious threat to human health from malignant tumors has not been effectively controlled. In order to improve the curative effect of cancer treatment, new breakthrough progress can be made only from the mechanism of tumor development. Cell activity is controlled by external signals. Abnormal cell signal transduction can lead to rapid proliferation and unlimited growth of malignant tumors. Therefore, the signal transduction pathway has become a new target for antitumor drug research. Chinese medicine treatment of cancer has a long history, with the advances in molecular biology, immunology, pharmacology and other traditional Chinese medicine, Chinese medicine and its active ingredients through the regulation of signal transduction pathways to achieve the prevention and treatment of cancer has become anti-tumor