目的进一步了解腹部侵袭性纤维瘤(AF)的概念、病理、可能分子机理及诊疗现状,寻找新的肿瘤治疗途径。方法对有关AF的定义、分子机理及临床研究文献进行综述并分析。结果腹部AF是罕见的良性纤维病变,是肌纤维母细胞异常增生的结果;AF的病理特征表明是一种良性疾病,但其具有“恶性”生物学行为,常累及周围脏器和血管而导致死亡。对于有临床症状或并发症的患者,完整切除肿瘤是首选治疗方法。即使手术保证阴性切缘也具有较高复发率,因而其治疗需要多学科综合治疗。结论 AF的发生机理极为复杂,其具体机理仍未阐明;目前最有效的治疗手段为手术切除;术后辅助放、化疗及其他治疗的作用尚需进一步研究。 Objective To further understand the concept, pathology, possible molecular mechanism of abdomen invasive fibroma (AF) and the status quo of diagnosis and treatment, and to search for new ways of tumor treatment. Methods The definition, molecular mechanism and clinical research about AF were reviewed and analyzed. Results Abdominal AF was a rare benign fibrosis and was the result of dysplasia of myofibroblasts. The pathological features of AF showed that it was a benign disease but had “malignant” biological behavior, which often involved the surrounding organs and blood vessels Cause death. For patients with clinical symptoms or complications, complete resection of the tumor is the preferred treatment. Even if the margin of negative surgical margin also has a high recurrence rate, so the treatment requires multidisciplinary treatment. Conclusions The mechanism of AF is extremely complicated. The exact mechanism has not been elucidated yet. At present, the most effective treatment is surgical resection. The role of postoperative adjuvant radiotherapy, chemotherapy and other treatments needs to be further studied.