1.引言药物领域中生物利用度和药物动力学术语是颇为新颖的。15～20年前,有关药物在体内的演变过程只有一肤浅的认识,对人或动物在给药后追踪生物相中的药迹几乎没有可靠的、选择性的及灵敏的方法可用。此后,情况大有变化,特别是色谱法的惊人发展和提高,使许多相似的新老药物的生物利用度和药物动力学得以测定。而且,色谱技艺的 1. Introduction The terms bioavailability and pharmacokinetics in the pharmaceutical arena are quite novel. There was only a shallow understanding of the evolution of drugs in the body 15 to 20 years ago and few reliable, selective and sensitive methods were available for tracking human or animal traces of drug in biological phases after administration. Since then, the situation has changed significantly, especially with the spectacular development and enhancement of chromatography, which has led to the determination of the bioavailability and pharmacokinetics of many similar new and old medicines. And, chromatographic skills